Imagine owning a Manhattan townhouse where you can wake up in a beautifully renovated duplex overlooking Lenox Avenue while your investment works for you downstairs. 273 Lenox Avenue offers an ownership opportunity that is remarkably difficult to find in Manhattan: a luxury owner's residence combined with two separate commercial spaces that can generate substantial income or serve as the perfect home for your own business. The upper two floors are configured as a spacious two-bedroom, two-bathroom duplex filled with natural light and soaring ceilings. Large windows frame vibrant Lenox Avenue views while offering the privacy and comfort of a true home. Whether you're entertaining, working remotely, or simply enjoying life in one of Harlem's most dynamic neighborhoods, this residence feels worlds apart from a typical Manhattan apartment. Below, two independent commercial units create exceptional flexibility. The street-level storefront enjoys direct retail access and outstanding visibility along Lenox Avenue, making it ideal for retail, gallery, showroom, medical, wellness, or professional office use. Above it, a completely separate second-floor office suite provides another income-producing space or the perfect headquarters for your own business. This is the rare property that adapts to your life. Live upstairs and lease both commercial spaces. Occupy one office while collecting rent from the other. Build your business below while eliminating your commute. Or lease all three units for a projected 7.14% capitalization rate, creating an investment that is nearly impossible to replicate at this price point. Extensively gut renovated in the 2010s, the building was thoughtfully modernized with separate HVAC systems serving each unit independently. A full-height, dry cellar with sidewalk hatch access provides exceptional storage rarely found in Manhattan buildings. Mixed-use properties of this caliber are exceedingly scarce. Finding one below $5 million is uncommon. Finding one under $3 million—offering a renovated owner's duplex, multiple commercial income streams, modern building systems, and extraordinary flexibility—is virtually unheard of. Whether you're an entrepreneur, physician, attorney, architect, creative professional, investor, or simply someone who wants to own the building they live in, 273 Lenox Avenue represents one of Harlem's most compelling owner-user opportunities.